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Androgen receptor CAG repeat polymorphism is associated with cognitive function in older men.
- Source :
-
Biological psychiatry [Biol Psychiatry] 2003 Nov 01; Vol. 54 (9), pp. 943-6. - Publication Year :
- 2003
-
Abstract
- Background: Androgen receptors are located throughout the brain, especially in regions involved with learning and memory. Different lengths of a CAG (glutamine) repeat polymorphism in exon 1 of the androgen receptor gene may influence androgen action, with longer repeat lengths conferring decreased androgen sensitivity.<br />Methods: We sought to determine if this CAG polymorphism was associated with cognition in older men.<br />Results: Among 301 community-dwelling white men (mean age, 73.0 +/- 7.1), greater CAG repeat length was associated with lower scores on three cognitive tests (p <.05 for all). In addition, 12 participants (9.8%) had cognitive impairment in the low tertile of CAG repeat length whereas 29 (16.3%) had cognitive impairment in the two higher tertiles (odds ratio = 1.8; 95% confidence interval =.9-3.7).<br />Conclusions: Research should be directed at identifying the mechanism for this association and to determine if treatment with testosterone prevents cognitive decline.
Details
- Language :
- English
- ISSN :
- 0006-3223
- Volume :
- 54
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Biological psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 14573323
- Full Text :
- https://doi.org/10.1016/s0006-3223(03)00115-x