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Activity of AZD2563, a novel oxazolidinone, against Staphylococcus aureus strains with reduced susceptibility to vancomycin or linezolid.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2003 Nov; Vol. 47 (11), pp. 3651-2. - Publication Year :
- 2003
-
Abstract
- The susceptibilities of clinical vancomycin-intermediate Staphylococcus aureus (VISA), heterogeneous VISA, and laboratory-generated linezolid-resistant S. aureus strains to the new oxazolidinone AZD2563 were assessed by agar dilution MIC determination. All clinical strains were susceptible to linezolid, and the linezolid MICs for them were equal to or twofold higher than those of AZD2563. Cross-resistance with linezolid was seen in laboratory-generated mutants, and for these strains the MIC of AZD2563 was twofold higher than that of linezolid.
- Subjects :
- Drug Resistance, Bacterial genetics
Humans
Linezolid
Microbial Sensitivity Tests
Staphylococcal Infections microbiology
Staphylococcus aureus genetics
Acetamides pharmacology
Anti-Infective Agents pharmacology
Oxazolidinones pharmacology
Staphylococcus aureus drug effects
Vancomycin Resistance genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0066-4804
- Volume :
- 47
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 14576139
- Full Text :
- https://doi.org/10.1128/AAC.47.11.3651-3652.2003