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[Silica nanoparticles modified as carriers for gene transfection].
- Source :
-
Yi chuan xue bao = Acta genetica Sinica [Yi Chuan Xue Bao] 2003 Jul; Vol. 30 (7), pp. 606-10. - Publication Year :
- 2003
-
Abstract
- The silica nanoparticles are modified by sodium iodine or sodium chloride with different concentration. Their ability to bind and protect plasmid DNA was demonstrated by agarose gel electrophoresis. The EGFP-N1 plasmid was transfected into HT1080 by combing silica nanoparticle. Eletromicroscope examine revealed that nanoparticle-DNA could enter into cells, these silica nanoparticles protect DNA against nuclease digestion and the GFP has an effective expression. In conclusion, these nanoparticles might be used as DNA carriers for gene transfection.
Details
- Language :
- Chinese
- ISSN :
- 0379-4172
- Volume :
- 30
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Yi chuan xue bao = Acta genetica Sinica
- Publication Type :
- Academic Journal
- Accession number :
- 14579527