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A new class of glycogen phosphorylase inhibitors.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2003 Nov 17; Vol. 13 (22), pp. 4125-8. - Publication Year :
- 2003
-
Abstract
- A new class of diacid analogues that binds at the AMP site not only are very potent but have approximately 10-fold selectivity in liver versus muscle glycogen phosphorylase (GP) in the in vitro assay. The synthesis, structure, and in vitro and in vivo biological evaluation of these liver selective glycogen phosphorylase inhibitors are discussed.
- Subjects :
- Adenosine Triphosphate metabolism
Amino Acid Sequence
Animals
Binding Sites
Glycogen Phosphorylase chemistry
Kinetics
Liver enzymology
Mice
Models, Molecular
Molecular Conformation
Naphthols pharmacology
Protein Conformation
Rats
Structure-Activity Relationship
Enzyme Inhibitors chemical synthesis
Enzyme Inhibitors pharmacology
Glycogen Phosphorylase antagonists & inhibitors
Naphthols chemical synthesis
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 13
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 14592521
- Full Text :
- https://doi.org/10.1016/j.bmcl.2003.08.046