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Predictors of long-term outcome in very preterm infants: gestational age versus neonatal cranial ultrasound.
- Source :
-
Pediatrics [Pediatrics] 2003 Nov; Vol. 112 (5), pp. 1108-14. - Publication Year :
- 2003
-
Abstract
- Objectives: To investigate the effect of gestational age at birth on the frequency of ultrasound-detected brain lesions in infants born at <33 weeks of gestation and to investigate whether the relationship between neonatal cranial ultrasound diagnosis and neurodevelopmental outcome at 8 years of age was independent of gestational age.<br />Methods: Eight hundred forty-seven infants born at <33 weeks of gestation, admitted to a single tertiary referral center between 1983 and 1988, underwent serial neonatal cranial ultrasound. At 8 years of age neurodevelopmental outcome was assessed by structured neurologic examination, psychometric tests (Wechsler Intelligence Scale for Children), tests of visuomotor integration (Beery) and motor impairment (Henderson-Stott). Infants were subdivided into a group born at <28 weeks and a group born at between 28 and 32 weeks. Neurodevelopmental outcome was analyzed for each ultrasound diagnosis.<br />Results: Hemorrhagic lesions such as germinal matrix/intraventricular hemorrhage and hemorrhagic parenchymal infarction were more frequent in infants born at <28 weeks. There was no difference in the frequency of cystic periventricular leucomalacia between the 2 groups. When neurodevelopmental outcome for each ultrasound diagnosis was compared, no significant difference was found between the 2 gestational age groups.<br />Conclusion: In the gestational age range studied, adverse neurodevelopmental outcome depends primarily on the type of the intracranial lesion rather than on gestational age.
- Subjects :
- Brain Damage, Chronic diagnostic imaging
Brain Damage, Chronic etiology
Cerebral Hemorrhage complications
Cerebral Hemorrhage diagnostic imaging
Cerebral Hemorrhage epidemiology
Cerebral Infarction complications
Cerebral Infarction diagnostic imaging
Cerebral Infarction epidemiology
Child
Developmental Disabilities diagnostic imaging
Developmental Disabilities etiology
Female
Follow-Up Studies
Gestational Age
Humans
Infant, Newborn
Leukomalacia, Periventricular complications
Leukomalacia, Periventricular diagnostic imaging
Leukomalacia, Periventricular epidemiology
Male
Prospective Studies
Psychomotor Performance
Brain Damage, Chronic epidemiology
Developmental Disabilities epidemiology
Echoencephalography
Infant, Premature
Subjects
Details
- Language :
- English
- ISSN :
- 1098-4275
- Volume :
- 112
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Pediatrics
- Publication Type :
- Academic Journal
- Accession number :
- 14595054
- Full Text :
- https://doi.org/10.1542/peds.112.5.1108