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Role of mitogen activated protein kinase cascade pathway and anti-stress response in liver transplantation.
- Source :
-
Hepatobiliary & pancreatic diseases international : HBPD INT [Hepatobiliary Pancreat Dis Int] 2003 May; Vol. 2 (2), pp. 191-5. - Publication Year :
- 2003
-
Abstract
- Objective: To explore the changes of mitogen activated protein kinase (MAPK) cascade pathway and anti-stress response of hepatocytes after liver transplantation.<br />Methods: Ten normal liver specimens and 18 punctured donor liver specimens were divided into 3 groups: A (control:10), B (no rejection:10) and C (acute rejection:8). MAPK, Ras, Jun and heat shock protein 70 (HSP70) were tested immunohistochemically while Ras and HSP70 were tested by in situ hybridization. All sections were subjected to image analysis.<br />Results: Protein expressions of MAPK, Ras and Jun were increased by an ascending order of groups A, B and C. The protein expression of HSP70 was the highest in group B but lower in group C. Expressions of Ras and HSP70 mRNA were consistent with those of protein.<br />Conclusions: The changes of the MAPK cascade pathway and anti-stress response of hepatocytes after liver transplantation are one of regulation mechanisms for protecting the hepatocytes from damage after liver transplantation. This mechanism is active to support individual survival
- Subjects :
- Gene Expression
HSP70 Heat-Shock Proteins genetics
HSP70 Heat-Shock Proteins metabolism
Humans
Immunohistochemistry
Proto-Oncogene Proteins c-jun metabolism
ras Proteins genetics
ras Proteins metabolism
Graft Rejection physiopathology
Liver Transplantation
MAP Kinase Signaling System physiology
Stress, Physiological physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1499-3872
- Volume :
- 2
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Hepatobiliary & pancreatic diseases international : HBPD INT
- Publication Type :
- Academic Journal
- Accession number :
- 14599967