Back to Search
Start Over
Yeast life-span extension by calorie restriction is independent of NAD fluctuation.
- Source :
-
Science (New York, N.Y.) [Science] 2003 Dec 19; Vol. 302 (5653), pp. 2124-2126. Date of Electronic Publication: 2003 Nov 06. - Publication Year :
- 2003
-
Abstract
- Calorie restriction (CR) slows aging in numerous species. In the yeast Saccharomyces cerevisiae, this effect requires Sir2, a conserved NAD+-dependent deacetylase. We report that CR reduces nuclear NAD+ levels in vivo. Moreover, the activity of Sir2 and its human homologue SIRT1 are not affected by physiological alterations in the NAD+:NADH ratio. These data implicate alternate mechanisms of Sir2 regulation by CR.
- Subjects :
- Acetaldehyde metabolism
Aerobiosis
CCAAT-Binding Factor genetics
CCAAT-Binding Factor metabolism
Caloric Restriction
Culture Media
DNA-Binding Proteins
Genes, Fungal
Genes, Reporter
Histidine metabolism
Hydro-Lyases genetics
Hydro-Lyases metabolism
Longevity
Magnetic Resonance Spectroscopy
Recombinant Fusion Proteins metabolism
Repressor Proteins genetics
Repressor Proteins metabolism
Saccharomyces cerevisiae genetics
Saccharomyces cerevisiae growth & development
Saccharomyces cerevisiae Proteins genetics
Saccharomyces cerevisiae Proteins metabolism
Sirtuin 1
Sirtuin 2
Transcription Factors genetics
Transcription Factors metabolism
Bacterial Proteins
Histone Deacetylases metabolism
NAD metabolism
Saccharomyces cerevisiae physiology
Silent Information Regulator Proteins, Saccharomyces cerevisiae metabolism
Sirtuins metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1095-9203
- Volume :
- 302
- Issue :
- 5653
- Database :
- MEDLINE
- Journal :
- Science (New York, N.Y.)
- Publication Type :
- Academic Journal
- Accession number :
- 14605207
- Full Text :
- https://doi.org/10.1126/science.1088697