Back to Search
Start Over
Synthesis and evaluation of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2003 Sep 01; Vol. 13 (17), pp. 2933-6. - Publication Year :
- 2003
-
Abstract
- A series of methyl ether derivatives of the vancomycin, teicoplanin, and ristocetin aglycon methyl esters was synthesized and their antimicrobial activity was established. These derivatives exhibit increased activity against VanB resistant strains of bacteria equipotent with that observed with sensitive bacteria.
- Subjects :
- Enterococcus faecalis drug effects
Methyl Ethers chemical synthesis
Methyl Ethers pharmacology
Microbial Sensitivity Tests
Ristocetin chemical synthesis
Ristocetin pharmacology
Staphylococcus aureus drug effects
Structure-Activity Relationship
Teicoplanin chemical synthesis
Teicoplanin pharmacology
Vancomycin chemical synthesis
Vancomycin pharmacology
Vancomycin Resistance
Anti-Infective Agents chemical synthesis
Anti-Infective Agents pharmacology
Ristocetin analogs & derivatives
Teicoplanin analogs & derivatives
Vancomycin analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 13
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 14611861
- Full Text :
- https://doi.org/10.1016/s0960-894x(03)00513-4