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Novel 3,4-dihydroquinolin-2(1H)-one inhibitors of human glycogen phosphorylase a.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2003 Dec 15; Vol. 13 (24), pp. 4385-8. - Publication Year :
- 2003
-
Abstract
- The preparation of a series of substituted indoles coupled to six- and seven-membered cyclic lactams is described and their role as human glycogen phosphorylase a inhibitors discussed. The SAR of the indole moiety and lactam ring are presented.
- Subjects :
- Enzyme Inhibitors chemical synthesis
Enzyme Inhibitors chemistry
Humans
Kinetics
Models, Molecular
Molecular Conformation
Quinolines chemistry
Structure-Activity Relationship
Enzyme Inhibitors pharmacology
Glycogen Phosphorylase antagonists & inhibitors
Quinolines chemical synthesis
Quinolines pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 13
- Issue :
- 24
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 14643331
- Full Text :
- https://doi.org/10.1016/j.bmcl.2003.09.022