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The human brain resonance of choline-containing compounds is similar in patients receiving lithium treatment and controls: an in vivo proton magnetic resonance spectroscopy study.
- Source :
-
Biological psychiatry [Biol Psychiatry] 1992 Nov 15; Vol. 32 (10), pp. 944-9. - Publication Year :
- 1992
-
Abstract
- Lithium specifically and potentially inhibits membrane transport of choline. However, the effect of lithium on human neuronal choline content is unknown. This study was performed to determine if lithium alters the human brain choline concentration in vivo. In vivo proton magnetic resonance spectroscopy was used to compare the relative brain concentration of choline-containing compounds in seven lithium-treated patients and six lithium-free controls. No significant difference was observed in the mean relative choline resonance between the patient and control groups. Lithium treatment did not appear to alter the overall brain content of choline-containing compounds. It remains possible that a component of these compounds, particularly free choline, is elevated during lithium treatment.
- Subjects :
- Adult
Aspartic Acid analogs & derivatives
Aspartic Acid metabolism
Bipolar Disorder metabolism
Bipolar Disorder psychology
Brain metabolism
Corpus Callosum drug effects
Corpus Callosum metabolism
Humans
Male
Parietal Lobe drug effects
Parietal Lobe metabolism
Phosphocreatine metabolism
Bipolar Disorder drug therapy
Brain drug effects
Choline metabolism
Lithium Carbonate therapeutic use
Magnetic Resonance Spectroscopy
Subjects
Details
- Language :
- English
- ISSN :
- 0006-3223
- Volume :
- 32
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Biological psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 1467379
- Full Text :
- https://doi.org/10.1016/0006-3223(92)90184-2