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A biased Valpha24+ T-cell repertoire leads to circulating NKT-cell defects in a multiple sclerosis patient at the onset of his disease.
- Source :
-
Immunology letters [Immunol Lett] 2003 Dec 15; Vol. 90 (2-3), pp. 223-8. - Publication Year :
- 2003
-
Abstract
- As natural killer T (NKT) cells have been implicated in the regulation of multiple sclerosis (MS), we investigated expression of the Valpha24JalphaQ canonical rearrangement in MS patients during relapses. We observed major changes in the entire blood Valpha24(+) T-cell repertoire. Seven of the eight patients showed a marked decrease in Valpha24(+) transcript number and a decrease in the diversity of the Valpha24(+) T-cell repertoire, with the exception of a few expanded clones. These perturbations, exacerbated in patient MS (A), led to circulating NKT cell defects.
- Subjects :
- Amino Acid Sequence
Cells, Cultured
Humans
Multiple Sclerosis blood
Multiple Sclerosis pathology
Receptors, Antigen, T-Cell, alpha-beta chemistry
Receptors, Antigen, T-Cell, alpha-beta genetics
Recurrence
Killer Cells, Natural immunology
Multiple Sclerosis immunology
Receptors, Antigen, T-Cell, alpha-beta immunology
T-Lymphocytes immunology
T-Lymphocytes metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0165-2478
- Volume :
- 90
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Immunology letters
- Publication Type :
- Academic Journal
- Accession number :
- 14687729
- Full Text :
- https://doi.org/10.1016/j.imlet.2003.09.014