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Pathogenesis of diseases associated with antineutrophil cytoplasm autoantibodies.
- Source :
-
Human immunology [Hum Immunol] 2004 Jan; Vol. 65 (1), pp. 1-12. - Publication Year :
- 2004
-
Abstract
- Little is known about the etiologies of diseases associated with circulating antineutrophil cytoplasm autoantibodies (ANCA), such as primary vasculitides and inflammatory bowel diseases. However, the understanding of immune mechanisms supposedly involved in the pathogenesis of these diseases is still growing. In the present review, we first focus on the mechanisms triggering the development of ANCA, including the potential role of microbial superantigens and the possible defect(s) in the progression of apoptosis or in the removal of apoptotic cells. We next concentrate on the contribution of ANCA to the clinical symptoms and on the pathogenic role of ANCA, including the accessibility of ANCA antigens as targets for circulating antibodies and the mode of action of ANCA. Mechanisms of neutrophil activation by ANCA include the engagement of Fcgamma receptors, the possible mechanisms of neutrophil-mediated tissue damage, and the neutrophil-endothelial interaction.
- Subjects :
- Animals
Apoptosis
Autoantigens immunology
Autoimmune Diseases immunology
Autoimmune Diseases pathology
Churg-Strauss Syndrome etiology
Churg-Strauss Syndrome immunology
Churg-Strauss Syndrome pathology
Endothelium, Vascular immunology
Endothelium, Vascular pathology
Granulomatosis with Polyangiitis etiology
Granulomatosis with Polyangiitis immunology
Granulomatosis with Polyangiitis pathology
Humans
Mice
Models, Animal
Myeloblastin
Neutrophils immunology
Neutrophils physiology
Peroxidase immunology
Serine Endopeptidases immunology
Superantigens immunology
T-Lymphocytes, Cytotoxic immunology
Vasculitis etiology
Vasculitis immunology
Vasculitis pathology
Antibodies, Antineutrophil Cytoplasmic immunology
Autoimmune Diseases etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0198-8859
- Volume :
- 65
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Human immunology
- Publication Type :
- Academic Journal
- Accession number :
- 14700590
- Full Text :
- https://doi.org/10.1016/j.humimm.2003.09.013