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A novel naphthanol glycoside from Terminalia arjuna with antioxidant and nitric oxide inhibitory activities.
- Source :
-
Die Pharmazie [Pharmazie] 2003 Dec; Vol. 58 (12), pp. 932-4. - Publication Year :
- 2003
-
Abstract
- A novel naphthanol glycoside, arjunaphthanoloside (1), was isolated from the stem bark of Terminalia arjuna and its structure was established as 2,3,6,7,8,9-hexahydroxynaphthalene-2-O-alpha-L(-)-rhamnoside by means of spectroscopic and chemical methods. Compound 1 showed potent antioxidant activity and inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated rat peritoneal macrophages.
- Subjects :
- Animals
Biphenyl Compounds
Cardiotonic Agents pharmacology
Free Radical Scavengers pharmacology
Glycosides chemistry
Hydrolysis
In Vitro Techniques
Lipopolysaccharides antagonists & inhibitors
Lipopolysaccharides pharmacology
Lipoproteins, LDL chemistry
Macrophages, Peritoneal drug effects
Macrophages, Peritoneal metabolism
Magnetic Resonance Spectroscopy
Naphthalenes chemistry
Nitric Oxide Synthase antagonists & inhibitors
Nitric Oxide Synthase metabolism
Nitric Oxide Synthase Type II
Picrates metabolism
Plant Bark chemistry
Plant Extracts pharmacology
Rats
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet
Superoxides metabolism
Antioxidants pharmacology
Glycosides pharmacology
Naphthalenes pharmacology
Nitric Oxide antagonists & inhibitors
Terminalia chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0031-7144
- Volume :
- 58
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Die Pharmazie
- Publication Type :
- Academic Journal
- Accession number :
- 14703977