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Mixed depressive features predict maniform switch during treatment of depression in bipolar I disorder.
- Source :
-
Journal of affective disorders [J Affect Disord] 2004 Feb; Vol. 78 (2), pp. 149-52. - Publication Year :
- 2004
-
Abstract
- Background: Case observations imply that depressed patients with mixed features are of high risk for maniform switch during acute treatment.<br />Methods: The medical records of 158 bipolar I depressives were examined with respect to mixed depressive features at admission, naturalistic medications, and maniform switch during inpatient treatment.<br />Results: Besides pharmacological variables, the number of mixed depressive symptoms (flight of ideas, racing thoughts, logorrhea, aggression, excessive social contact, increased drive, irritability, and distractibility) at admission was associated with a higher risk for, and the acceleration of, maniform switch during inpatient treatment.<br />Limitations: This was a retrospective study in patients receiving naturalistic treatment. The cohort was hospital based and thus not representative of the full range of bipolar affective disorder.<br />Conclusions: In line with recent studies, our results underline the factors inherent in subjects at a higher risk of switch. Investigation of the relationships between several inherent factors and their interactions with pharmacological treatments may be important in resolving the controversy surrounding antidepressant-induced mania. Further validation studies on mixed depression are warranted.
Details
- Language :
- English
- ISSN :
- 0165-0327
- Volume :
- 78
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of affective disorders
- Publication Type :
- Academic Journal
- Accession number :
- 14706725
- Full Text :
- https://doi.org/10.1016/s0165-0327(02)00265-3