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Framingham stroke risk profile and lowered cognitive performance.

Authors :: Elias MF
Sullivan LM
D'Agostino RB
Elias PK
Beiser A
Au R
Seshadri S
DeCarli C
Wolf PA
Source :: Stroke [Stroke] 2004 Feb; Vol. 35 (2), pp. 404-9. Date of Electronic Publication: 2004 Jan 15.
Publication Year :: 2004
Abstract: Background and Purpose: The primary objective of this work was to describe the relationships between 10-year risk for stroke and multiple measures of cognitive performance for a large community-based sample of individuals who were free of clinical stroke and dementia at the time of risk assessment.<br />Methods: Participants were 1011 men and 1164 women from the Framingham Offspring Study. The Framingham Stroke Risk Profile was used to assess 10-year risk of stroke. Using a cross-sectional design, we assessed 10-year risk of stroke, the predictor variable, and cognitive performance, the outcome variable, at examination 7 of the Framingham Offspring Study. Multivariable linear regression models were used to relate 10-year risk of stroke to cognitive tests measuring multiple domains of cognitive functioning.<br />Results: With statistical adjustment for age, education, sex, and other correlates of both stroke and cognitive ability, an inverse association between increments in 10-year risk of stroke and cognitive performance level was observed for tests indexing visual-spatial memory, attention, organization, scanning, and abstract reasoning.<br />Conclusions: In stroke- and dementia-free individuals, higher 10-year risk for stroke is associated with performance decrements in multiple cognitive domains.