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Umbilical cord blood transplantation in adults using myeloablative and nonmyeloablative preparative regimens.
- Source :
-
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation [Biol Blood Marrow Transplant] 2004 Jan; Vol. 10 (1), pp. 1-22. - Publication Year :
- 2004
-
Abstract
- Unrelated umbilical cord blood (UCB) transplantation has recently been explored in an increasing number of adult patients. The relative ease of procurement and the lower-than-anticipated risk of severe acute graft-versus-host disease has made UCB transplantation an appealing alternative to bone marrow-derived hematopoietic stem cells. The use of reduced-intensity or nonmyeloablative preparative regimens to allow engraftment of UCB broadens the scope of patients who may benefit from allogeneic immunotherapy, including elderly and medically infirm patients with no matched sibling donor. This review summarizes the available data on the use of UCB as an alternative source of hematopoietic stem cell transplantation in adult patients.
- Subjects :
- Adult
Age Factors
Child
Cord Blood Stem Cell Transplantation adverse effects
Cord Blood Stem Cell Transplantation mortality
Humans
Immune System physiology
Regeneration
Tissue Donors
Transplantation Conditioning adverse effects
Transplantation Conditioning mortality
Treatment Outcome
Cord Blood Stem Cell Transplantation methods
Transplantation Conditioning methods
Subjects
Details
- Language :
- English
- ISSN :
- 1083-8791
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 14752775
- Full Text :
- https://doi.org/10.1016/j.bbmt.2003.09.009