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Potential warfarin-ciprofloxacin interaction in patients receiving long-term anticoagulation.
- Source :
-
Pharmacotherapy [Pharmacotherapy] 1992; Vol. 12 (6), pp. 435-9. - Publication Year :
- 1992
-
Abstract
- This study prospectively evaluated the potential interaction between the oral anticoagulant warfarin and the quinolone antimicrobial agent ciprofloxacin. After a 10-day placebo lead-in phase, 16 patients stabilized with long-term warfarin therapy were randomized to receive ciprofloxacin 500 mg or a matching placebo twice/day for 10 days. International normalized ratios (INRs) measured by both standard laboratory analysis and by Coumatrak (finger-stick) methods were evaluated at 3- to 5-day intervals. No patient experienced a significant increase in INR. No patient experienced a bleeding event. These data support the fact that a warfarin-ciprofloxacin interaction does not routinely occur at this dosage and duration of ciprofloxacin therapy.
- Subjects :
- Adult
Aged
Ciprofloxacin administration & dosage
Ciprofloxacin therapeutic use
Double-Blind Method
Drug Interactions
Female
Humans
Male
Middle Aged
Prospective Studies
Prothrombin Time
Time Factors
Warfarin administration & dosage
Warfarin therapeutic use
Ciprofloxacin pharmacology
Warfarin pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0277-0008
- Volume :
- 12
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Pharmacotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 1492006