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[Content of different cytokines in the blood of healthy children and their siblings who are either.positive or negative for diabetes-associated autoantibodies (GADA, 1A-2A, IAA)].
- Source :
-
Likars'ka sprava [Lik Sprava] 2003 Dec (8), pp. 26-9. - Publication Year :
- 2003
-
Abstract
- Content of different cytokines (IF alpha, TNF alpha, IL-1 alpha, IL-4, IL-6 and IL-10) was examined in the blood serum in two groups of healthy children-siblings with type 1 diabetes mellitus with and without revealed insulin autoantibodies against pancreatic islets (GADA, IA-2A and IAA) by enzyme-like immunosorbent assay (ELISA). In the group of patients with two and more revealed autoantibodies the higher indices in the number of IF alpha, TNF alpha and IL-6, and the decrease in the level of IL-4 comparing with the group of children with negative reaction to diabetes associated autoantibodies were more often observed.
- Subjects :
- Adolescent
Child
Diabetes Mellitus, Type 1 blood
Enzyme-Linked Immunosorbent Assay
Female
Glutamate Decarboxylase blood
Glutamate Decarboxylase immunology
Humans
Insulin blood
Insulin immunology
Male
Protein Tyrosine Phosphatase, Non-Receptor Type 1
Protein Tyrosine Phosphatases blood
Autoantibodies blood
Autoantibodies immunology
Cytokines blood
Diabetes Mellitus, Type 1 immunology
Siblings
Subjects
Details
- Language :
- Russian
- ISSN :
- 1019-5297
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Likars'ka sprava
- Publication Type :
- Academic Journal
- Accession number :
- 14965001