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In vitro activities of 3-(halogenated phenyl)-5-acyloxymethyl- 2,5-dihydrofuran-2-ones against common and emerging yeasts and molds.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2004 Mar; Vol. 48 (3), pp. 873-8. - Publication Year :
- 2004
-
Abstract
- Three 3-(halogenated phenyl)-5-acyloxymethyl-2,5-dihydrofuran-2-ones were evaluated for activity against 191 strains of common and emerging yeasts and Aspergillus species by the broth microdilution test performed according to NCCLS guidelines. The furanone derivatives displayed broad-spectrum in vitro activity against potentially pathogenic yeasts and molds, especially Aspergillus spp. (MIC <or= 2.0 microg/ml) and fluconazole-resistant yeast isolates, including Candida glabrata and Saccharomyces cerevisiae. The 4-bromophenyl derivative was the most effective derivative against the majority of species tested, except for the Candida tropicalis and C. glabrata strains, which were more susceptible to the 3-chlorophenyl derivative. The 3,4-dichlorophenyl derivative possessed a lesser in vitro antifungal effect. The potential of further experiments on animal infection and clinical studies is supported by the relatively low cytotoxicity and acute toxicity of the 4-bromophenyl compound. Thus, the halogenated 3-phenyl-5-acyloxymethyl derivatives of 2,5-dihydrofuran-2-one represent a novel, promising group of compounds with significant activity against relevant opportunistic fungi that are pathogenic to humans.
- Subjects :
- Animals
Antifungal Agents toxicity
Antineoplastic Agents pharmacology
Drug Resistance, Fungal
Fluconazole pharmacology
Fungi ultrastructure
Furans toxicity
Humans
Lethal Dose 50
Leukemia L1210 drug therapy
Male
Mice
Microbial Sensitivity Tests
Mycoses microbiology
Yeasts ultrastructure
Antifungal Agents pharmacology
Fungi drug effects
Furans pharmacology
Yeasts drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0066-4804
- Volume :
- 48
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 14982778
- Full Text :
- https://doi.org/10.1128/AAC.48.3.873-878.2004