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Control of mitochondrial integrity by Bcl-2 family members and caspase-independent cell death.
- Source :
-
Biochimica et biophysica acta [Biochim Biophys Acta] 2004 Mar 01; Vol. 1644 (2-3), pp. 133-47. - Publication Year :
- 2004
-
Abstract
- Programmed cell death (PCD) is essential for normal development and maintenance of tissue homeostasis in multicellular organisms. While it is now evident that PCD can take many different forms, apoptosis is probably the most well-defined cell death programme. The characteristic morphological and biochemical features associated with this highly regulated form of cell death have until recently been exclusively attributed to the caspase family of cysteine proteases. As a result, many investigators affiliate apoptosis with its pivotal execution system, i.e. caspase activation. However, it is becoming increasingly clear that PCD or apoptosis can also proceed in a caspase-independent manner and maintain key characteristics of apoptosis. Mitochondrial integrity is central to both caspase-dependent and-independent cell death. The release of pro-apoptotic factors from the mitochondrial intermembrane space is a key event in a cell's commitment to die and is under the tight regulation of the Bcl-2 family. However, the underlying mechanisms governing the efflux of these pro-death molecules are largely unknown. This review will focus on the regulation of mitochondrial integrity by Bcl-2 family members with particular attention to the controlled release of factors involved in caspase-independent cell death.
- Subjects :
- Animals
Apoptosis Inducing Factor
Caspases metabolism
Endodeoxyribonucleases metabolism
Flavoproteins physiology
High-Temperature Requirement A Serine Peptidase 2
Humans
Intracellular Membranes metabolism
Membrane Proteins physiology
Membrane Transport Proteins metabolism
Mitochondria ultrastructure
Mitochondrial Proteins physiology
Permeability
Serine Endopeptidases physiology
Apoptosis
Mitochondria metabolism
Proto-Oncogene Proteins c-bcl-2 physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0006-3002
- Volume :
- 1644
- Issue :
- 2-3
- Database :
- MEDLINE
- Journal :
- Biochimica et biophysica acta
- Publication Type :
- Academic Journal
- Accession number :
- 14996498
- Full Text :
- https://doi.org/10.1016/j.bbamcr.2003.08.011