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Overanticoagulation associated with combined use of lactulose and acenocoumarol or phenprocoumon.

Authors :
Visser LE
Penning-van Beest FJ
Wilson JH
Vulto AG
Kasbergen AA
De Smet PA
Hofman A
Stricker BH
Source :
British journal of clinical pharmacology [Br J Clin Pharmacol] 2004 Apr; Vol. 57 (4), pp. 522-4.
Publication Year :
2004

Abstract

Some medical textbooks on drug interactions take note of the potential interaction between laxatives and coumarin anticoagulants, but epidemiological evidence that this interaction is of practical importance is lacking. We conducted a follow-up study in a large population-based cohort to investigate which laxatives are associated with overanticoagulation during therapy with coumarins. Of the 1124 patients in the cohort, 351 developed an International Normalized Ratio > or = 6.0. The only laxative with a moderate but significantly increased relative risk of overanticoagulation was lactulose (relative risk 3.4, 95% confidence interval 2.2, 5.3). In view of the widespread use of lactulose, especially among the elderly, awareness of this potential drug interaction is required.

Details

Language :
English
ISSN :
0306-5251
Volume :
57
Issue :
4
Database :
MEDLINE
Journal :
British journal of clinical pharmacology
Publication Type :
Academic Journal
Accession number :
15025752
Full Text :
https://doi.org/10.1046/j.1365-2125.2003.02036.x