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Expression of the homeobox gene barx2 in the gut.
- Source :
-
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society [J Histochem Cytochem] 2004 Apr; Vol. 52 (4), pp. 541-4. - Publication Year :
- 2004
-
Abstract
- Barx2 is a member of the Bar class of homeobox genes and has been shown to regulate specific cell adhesion molecules, L1, Ng-CAM, N-CAM, and cadherin 6. By Northern blotting and in situ hybridization, we show that Barx2 is expressed throughout the gut and is located in epithelial cells of the proliferative and differentiative regions of the stomach, esophagus, and intestine. Barx2 was expressed in muscle cells of the muscularis externa and also showed a graded pattern of expression in intestinal enterocytes, decreasing in a crypt-to-villous direction. We speculate that Barx2 may regulate cell adhesion molecules in epithelial cells of the gut.
- Subjects :
- Adenocarcinoma
Animals
Blotting, Northern
Cell Differentiation
Cell Division
Cell Line, Tumor
Colonic Neoplasms
Female
Gastric Mucosa cytology
Humans
In Situ Hybridization
Intestinal Mucosa cytology
Rats
Rats, Sprague-Dawley
Esophagus metabolism
Gastric Mucosa metabolism
Homeodomain Proteins biosynthesis
Intestinal Mucosa metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0022-1554
- Volume :
- 52
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
- Publication Type :
- Academic Journal
- Accession number :
- 15034005
- Full Text :
- https://doi.org/10.1177/002215540405200412