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Identification of sperm immunoreactive antigens for immunocontraceptive purposes: a review.
- Source :
-
Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2004 Mar 18; Vol. 2, pp. 11. Date of Electronic Publication: 2004 Mar 18. - Publication Year :
- 2004
-
Abstract
- Antisperm antibodies (ASA) may be a reason of infertility in some individuals. They may affect pre- as well as post-fertilization stages of the reproductive process. There is ongoing progress in the identification of sperm antigens related to fertilization. The employed methods for this purpose include recombinant DNA technology and the most advanced proteomic analysis. This paper enlists the different approaches undertaken in order to identify and characterize the immunoreactive sperm antigens. We have mainly focused on those, which have been already studied in regard of their immunocontraceptive potential, although it has been impossible to include all published data concerning the topic in a single article. Few novel sperm auto- and isoantigens, discovered recently, have also been reviewed even if their role in fertilization has not been yet established.
- Subjects :
- Animals
Antigens genetics
Antigens immunology
Contraception, Immunologic methods
Cytoskeletal Proteins
Female
Glycoproteins genetics
Glycoproteins immunology
Glycoproteins metabolism
Humans
Isoantigens genetics
Isoantigens immunology
Isoantigens metabolism
Male
Seminal Plasma Proteins genetics
Seminal Plasma Proteins immunology
Seminal Plasma Proteins metabolism
Spermatozoa immunology
Zyxin
Antibodies pharmacology
Antigens metabolism
Fertilization drug effects
Spermatozoa metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1477-7827
- Volume :
- 2
- Database :
- MEDLINE
- Journal :
- Reproductive biology and endocrinology : RB&E
- Publication Type :
- Academic Journal
- Accession number :
- 15035665
- Full Text :
- https://doi.org/10.1186/1477-7827-2-11