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Minireview: Gut peptides regulating satiety.

Authors :
Druce MR
Small CJ
Bloom SR
Source :
Endocrinology [Endocrinology] 2004 Jun; Vol. 145 (6), pp. 2660-5. Date of Electronic Publication: 2004 Mar 24.
Publication Year :
2004

Abstract

The gastrointestinal tract and the pancreas release hormones regulating satiety and body weight. Ghrelin stimulates appetite, and glucagon-like peptide-1, oxyntomodulin, peptide YY, cholecystokinin, and pancreatic polypeptide inhibit appetite. These gut hormones act to markedly alter food intake in humans and rodents. Obesity is the current major cause of premature death in the United Kingdom, killing almost 1000 people per week. Worldwide, its prevalence is accelerating. There is currently no effective answer to the pandemic of obesity, but replacement of the low levels of peptide YY observed in the obese may represent an effective antiobesity therapy.

Details

Language :
English
ISSN :
0013-7227
Volume :
145
Issue :
6
Database :
MEDLINE
Journal :
Endocrinology
Publication Type :
Academic Journal
Accession number :
15044353
Full Text :
https://doi.org/10.1210/en.2004-0089