Back to Search
Start Over
Changes in the haemodynamics of large arteries induced by single doses of nicardipine, enalapril, atenolol and urapidil.
- Source :
-
European journal of clinical pharmacology [Eur J Clin Pharmacol] 1992; Vol. 43 (1), pp. 7-10. - Publication Year :
- 1992
-
Abstract
- Haemodynamic changes in the carotid and brachial arteries produced by single doses of four anti-hypertensive drugs (nicardipine, enalapril, atenolol, and urapidil) have been studied in 12 patients with essential hypertension. Measurements were performed noninvasively using a mechanographic method and B-mode pulsed Doppler ultrasonography. Within 7 h all of the drugs had caused a significant reduction in blood pressure, whereas heart rate showed a significant change only after atenolol. All the drugs produced a marked reduction in brachial pulse-wave velocity. Only nicardipine caused a significant reduction in vessel wall tension both in the carotid and brachial arteries, while brachial peripheral resistance was significantly reduced by all the drugs except atenolol. Neither atenolol nor enalapril caused any significant reduction in carotid peripheral resistance. The results show that all four antihypertensive drugs led to a beneficial increase in arterial compliance despite their different effects on peripheral resistance.
- Subjects :
- Adult
Antihypertensive Agents therapeutic use
Atenolol pharmacology
Atenolol therapeutic use
Blood Pressure drug effects
Brachial Artery physiopathology
Carotid Arteries physiopathology
Enalapril pharmacology
Enalapril therapeutic use
Heart Rate drug effects
Humans
Male
Middle Aged
Nicardipine pharmacology
Nicardipine therapeutic use
Piperazines pharmacology
Piperazines therapeutic use
Vascular Resistance drug effects
Antihypertensive Agents pharmacology
Brachial Artery drug effects
Carotid Arteries drug effects
Hemodynamics drug effects
Hypertension drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0031-6970
- Volume :
- 43
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European journal of clinical pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 1505613
- Full Text :
- https://doi.org/10.1007/BF02280746