Back to Search
Start Over
A role for lipoprotein lipase during synaptic remodeling in the adult mouse brain.
- Source :
-
Neurobiology of disease [Neurobiol Dis] 2004 Apr; Vol. 15 (3), pp. 510-9. - Publication Year :
- 2004
-
Abstract
- Lipoprotein lipase (LPL) is a member of a lipase family known to hydrolyze triglyceride molecules found in lipoprotein particles. This particular lipase also has a role in the binding of lipoprotein particles to different cell-surface receptors. LPL has been identified in the brain but has no specific function yet. This study aimed at elucidating the role of LPL in the brain in response to injury. Mice were subjected to hippocampal deafferentation using the entorhinal cortex lesion and mRNA and protein expression were assessed over a time-course of degeneration/reinnervation. Hippocampal LPL levels peaked at 2 days post-lesion (DPL) both at the mRNA and protein levels. No change was observed for receptors of the LDL-receptor family or RAP at DPL 2 in the hippocampus but the glia-specific syndecan-4 was found to be significantly upregulated at DPL 2. These results suggest that LPL is involved in the recycling of cholesterol and lipids released from degenerating terminals after a lesion through a syndecan-4-dependent pathway.
- Subjects :
- Animals
Apolipoproteins E metabolism
Brain Injuries pathology
Electrophoresis, Gel, Two-Dimensional
Immunoblotting
In Situ Hybridization
Male
Membrane Glycoproteins metabolism
Mice
Nerve Degeneration pathology
Nerve Regeneration physiology
Proteoglycans metabolism
RNA, Messenger analysis
Receptors, LDL metabolism
Reverse Transcriptase Polymerase Chain Reaction
Syndecan-4
Brain Injuries enzymology
Lipoprotein Lipase biosynthesis
Nerve Degeneration enzymology
Synapses enzymology
Subjects
Details
- Language :
- English
- ISSN :
- 0969-9961
- Volume :
- 15
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Neurobiology of disease
- Publication Type :
- Academic Journal
- Accession number :
- 15056458
- Full Text :
- https://doi.org/10.1016/j.nbd.2003.12.001