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[Relationship between coronary flow reserve and recovery of regional left ventricular function in patients with tako-tsubo-like transient left ventricular dysfunction].

Authors :
Kume T
Akasaka T
Kawamoto T
Watanabe N
Yoshitani H
Akiyama M
Koyama Y
Neishi Y
Tsukiji M
Yoshida K
Source :
Journal of cardiology [J Cardiol] 2004 Mar; Vol. 43 (3), pp. 123-9.
Publication Year :
2004

Abstract

Objectives: This study assessed the relationship between coronary flow reserve and functional recovery of left ventricular wall motion in patients with tako-tsubo-like transient left ventricular dysfunction.<br />Methods: Coronary flow reserve was measured using the Doppler guide wire technique in the left descending coronary artery in nine consecutive patients (three men, six women, mean age 71 +/- 11 years) with tako-tsubo-like transient left ventricular dysfunction. Regional wall motion was analyzed to estimate anterior wall motion score index (anterior WMSI) by transthoracic echocardiography on admission and 3 weeks after the onset of symptoms.<br />Results: Anterior WMSI was 2.2 +/- 0.4 on admission and improved to 1.4 +/- 0.5 at 3 weeks later (p < 0.001). Coronary flow reserve on admission was not correlated to the anterior WMSI on admission (r = 0.19, p = 0.63). However, coronary flow reserve on admission was correlated to the improvement in anterior WMSI (r = 0.74, p = 0.02).<br />Conclusions: Coronary microcirculation is damaged in acute phase of tako-tsubo-like transient left ventricular dysfunction. The severity of coronary microvascular dysfunction influences the degree of left ventricular wall motion recovery.

Details

Language :
Japanese
ISSN :
0914-5087
Volume :
43
Issue :
3
Database :
MEDLINE
Journal :
Journal of cardiology
Publication Type :
Academic Journal
Accession number :
15067800