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The role of endothelium in the phenylephrine-induced oscillatory responses of rabbit mesenteric arteries.
- Source :
-
Japanese journal of pharmacology [Jpn J Pharmacol] 1992 May; Vol. 59 (1), pp. 37-41. - Publication Year :
- 1992
-
Abstract
- Phenylephrine-induced oscillatory contractions in rabbit mesenteric arteries were investigated in vitro. Adrenergic, cholinergic, or histamine antagonists as well as cyclooxygenase and lipoxygenase inhibitors had no effect on this phenylephrine-induced oscillation. The removal of extracellular calcium ions or treatment with a calcium antagonist reduced the amplitude and frequency of the oscillation. Removal of the endothelium or treatment with inhibitors of the synthesis or the target enzyme of endothelium-derived relaxing factor (EDRF) also reduced the amplitude and frequency of the oscillation. In a perfusion bioassay, the perfusate from an endothelium-intact arterial segment induced oscillation of an endothelium-denuded arterial ring recipient. These results suggest that phenylephrine-induced oscillation is mediated by an endothelium-derived factor such as EDRF and depends on the influx of extracellular calcium ions.
- Subjects :
- Animals
Arginine analogs & derivatives
Arginine pharmacology
Autonomic Agents pharmacology
Cyclooxygenase Inhibitors pharmacology
Endothelium, Vascular drug effects
Histamine Antagonists pharmacology
Lipoxygenase Inhibitors pharmacology
Male
Mesenteric Arteries physiology
Methylene Blue pharmacology
Muscle Contraction drug effects
Muscle, Smooth, Vascular drug effects
Muscle, Smooth, Vascular physiology
Rabbits
omega-N-Methylarginine
Calcium metabolism
Endothelium, Vascular physiology
Mesenteric Arteries drug effects
Nitric Oxide physiology
Phenylephrine pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 0021-5198
- Volume :
- 59
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Japanese journal of pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 1507655
- Full Text :
- https://doi.org/10.1254/jjp.59.37