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v-Src induces elevated levels of diglyceride by stimulation of phosphatidylcholine hydrolysis.

Authors :
Wyke AW
Cook SJ
MacNulty EE
Wakelam MJ
Source :
Cellular signalling [Cell Signal] 1992 May; Vol. 4 (3), pp. 267-74.
Publication Year :
1992

Abstract

When Rat-1 cells bearing the ts LA29 mutant of Rous sarcoma virus (Rat1 LA29) are shifted from restrictive to permissive temperature, the pp60v-Src tyrosine kinase is activated and there is an increase in the cellular level of sn1,2-diacylglycerol (DRG) within 30 min which is not accompanied by increased inositol phospholipid hydrolysis. Temperature shift also increases the hydrolysis of phosphatidylcholine (PC), as determined by an increase in the generation of water soluble choline metabolites. Transphosphatidylation studies have shown that this occurs at least in part via a phospholipase D (PLD) catalysed pathway.

Details

Language :
English
ISSN :
0898-6568
Volume :
4
Issue :
3
Database :
MEDLINE
Journal :
Cellular signalling
Publication Type :
Academic Journal
Accession number :
1510877
Full Text :
https://doi.org/10.1016/0898-6568(92)90066-h