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Islet cell autoimmunity in a triethnic adult population of the Third National Health and Nutrition Examination Survey.
- Source :
-
Diabetes [Diabetes] 2004 May; Vol. 53 (5), pp. 1293-302. - Publication Year :
- 2004
-
Abstract
- Markers of humoral islet cell autoimmunity, such as autoantibodies (AAs) against the 65-kDa isoform of GAD (GAD65), serve as determinants of risk for autoimmune diabetes. Despite the high prevalence of diabetes in U.S. racial and ethnic minority adult populations, little is known concerning the prevalence of GAD65 AA in these groups. We estimated the prevalence of GAD65 AA in 1,064 diabetic and 1,036 nondiabetic participants who were 40-90 years of age from the Third National Health and Nutrition Examination Survey (NHANES III), which provides a representative ethnic sample of the U.S. diabetic population. The prevalence of GAD65 AA was higher in diabetic participants compared with nondiabetic participants in non-Hispanic whites (n = 920; 6.3% vs. 2.0%; P = 0.001) and non-Hispanic blacks (n = 534; 3.7% vs. 1.3%; P = 0.08) but not in Mexican Americans (n = 646; 1.2% vs. 2.6%; P = 0.18). Among diabetic non-Hispanic whites and non-Hispanic blacks, being GAD65 AA positive was associated with lower BMI and C-peptide (P < 0.05). These results may reflect the outcome of an autoimmune process leading to beta-cell destruction/dysfunction in non-Hispanic white and non-Hispanic black adult diabetic patients as it occurs in a similar manner in type 1 diabetes. Among diabetic Mexican Americans, the lower prevalence of GAD65 AA suggests a lower frequency of autoimmune-related diabetes.
- Subjects :
- Aged
Aged, 80 and over
Autoantibodies analysis
Black People statistics & numerical data
Case-Control Studies
Female
Glutamate Decarboxylase immunology
Humans
Isoenzymes immunology
Male
Mexican Americans statistics & numerical data
Middle Aged
White People statistics & numerical data
Autoimmunity
Diabetes Mellitus ethnology
Diabetes Mellitus immunology
Islets of Langerhans immunology
Nutrition Surveys
Subjects
Details
- Language :
- English
- ISSN :
- 0012-1797
- Volume :
- 53
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Diabetes
- Publication Type :
- Academic Journal
- Accession number :
- 15111499
- Full Text :
- https://doi.org/10.2337/diabetes.53.5.1293