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Synthesis and evaluation of oxazaborolidines for antibacterial activity against Streptococcus mutans.
- Source :
-
Journal of medicinal chemistry [J Med Chem] 2004 May 06; Vol. 47 (10), pp. 2409-10. - Publication Year :
- 2004
-
Abstract
- Several representative oxazaborolidines have been synthesized and evaluated against S. mutans for antibacterial activity. This is the first reported antibacterial activity of this class of compounds. The minimal inhibitory concentration values ranged from 0.53 to 6.75 mM.
- Subjects :
- Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Boron Compounds chemistry
Boron Compounds pharmacology
Heterocyclic Compounds, 1-Ring chemistry
Heterocyclic Compounds, 1-Ring pharmacology
Microbial Sensitivity Tests
Stereoisomerism
Structure-Activity Relationship
Anti-Bacterial Agents chemical synthesis
Boron Compounds chemical synthesis
Heterocyclic Compounds, 1-Ring chemical synthesis
Streptococcus mutans drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0022-2623
- Volume :
- 47
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 15115381
- Full Text :
- https://doi.org/10.1021/jm049899b