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Determination of HIV type 1 CRF01_AE gag p17 and env-V3 consensus sequences for HIV/AIDS vaccine design.
- Source :
-
AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2004 Mar; Vol. 20 (3), pp. 337-40. - Publication Year :
- 2004
-
Abstract
- A molecular epidemiological study of the gag p17 and env-V3 regions on HIV-infected drug users and blood donors was carried out in northern Thailand from 1998 through 2002 to determine the predominant subtype and consensus sequence (CS) for circulating HIV-1 strains. CRF01_AE was concluded to be a predominant strain and the nucleotide CSs in gag p17 and env-V3 showed only 1.26% and no difference from CS in the Los Alamos database, respectively. Our env-V3 CS was identical to the previously published CSs, suggesting that the CS was very conserved from 1990 through 2002 in Thailand. Gag p17 and env-V3 nucleotide sequences of seroconvertors in our subjects were quite similar to the CS and conserved for at least 9 and 6 years postinfection, respectively. These results suggest that the CS approach to the HIV-1 antigen design could overcome HIV diversity and help us develop an effective HIV/AIDS vaccine.
- Subjects :
- Blood Donors
HIV Infections epidemiology
HIV Infections virology
HIV-1 classification
HIV-1 genetics
Humans
Molecular Epidemiology
Molecular Sequence Data
Sequence Analysis, DNA
Substance Abuse, Intravenous complications
Thailand epidemiology
gag Gene Products, Human Immunodeficiency Virus
AIDS Vaccines
Consensus Sequence
Drug Design
Gene Products, gag genetics
HIV Antigens genetics
HIV Envelope Protein gp120 genetics
Peptide Fragments genetics
Viral Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0889-2229
- Volume :
- 20
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- AIDS research and human retroviruses
- Publication Type :
- Academic Journal
- Accession number :
- 15117457
- Full Text :
- https://doi.org/10.1089/088922204322996572