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Involvement of substance P in scratching behaviour in an atopic dermatitis model.

Authors :
Ohmura T
Hayashi T
Satoh Y
Konomi A
Jung B
Satoh H
Source :
European journal of pharmacology [Eur J Pharmacol] 2004 May 03; Vol. 491 (2-3), pp. 191-4.
Publication Year :
2004

Abstract

Substance P is speculated to be a key mediator of itching in atopic dermatitis, possibly acting via the tachykinin NK1 receptor. Thus, we examined the effect of a tachykinin NK1 antagonist, BIIF 1149 CL, on scratching behaviour in a picrylchloride-induced dermatitis model in NC/Nga mice. BIIF 1149 CL ((S)-N-[2-[3,5-bis(trifluoromethyl) phenyl]ethyl]-4-(cyclopropylmethyl)-N-methyl-alpha-phenyl-1-piperazineacetamide, monohydrochloride, monohydrate) at a dose of 100 mg/kg, p.o., significantly inhibited scratching behaviour immediately after administration, and the effect continued up to 6 h. The results suggest that clinical trials of tachykinin NK1 antagonists for the treatment of itching in atopic dermatitis patients would be warranted.<br /> (Copyright 2004 Elsevier B.V.)

Details

Language :
English
ISSN :
0014-2999
Volume :
491
Issue :
2-3
Database :
MEDLINE
Journal :
European journal of pharmacology
Publication Type :
Academic Journal
Accession number :
15140636
Full Text :
https://doi.org/10.1016/j.ejphar.2004.03.047