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Control of DNA synthesis and mitosis by the Skp2-p27-Cdk1/2 axis.
- Source :
-
Molecular cell [Mol Cell] 2004 May 21; Vol. 14 (4), pp. 414-6. - Publication Year :
- 2004
-
Abstract
- A new study reveals a novel role for p27 in inhibiting Cdk1 activity at G2/M and shows that p27 deficiency almost completely rescues the aberrations observed in Skp2(-/-) mice, demonstrating that p27 is the principal downstream effector of the SCF(Skp2) ubiquitin ligase.
- Subjects :
- Animals
Cyclin-Dependent Kinase Inhibitor p27
G2 Phase genetics
Humans
Mice
Mice, Knockout
S-Phase Kinase-Associated Proteins genetics
SKP Cullin F-Box Protein Ligases genetics
CDC2 Protein Kinase genetics
Cell Cycle Proteins genetics
DNA Replication genetics
Mitosis genetics
S-Phase Kinase-Associated Proteins metabolism
Tumor Suppressor Proteins genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1097-2765
- Volume :
- 14
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Molecular cell
- Publication Type :
- Academic Journal
- Accession number :
- 15149588
- Full Text :
- https://doi.org/10.1016/s1097-2765(04)00268-0