Back to Search
Start Over
DNA interactions of cobalt(III) mixed-polypyridyl complexes containing asymmetric ligands.
- Source :
-
Journal of inorganic biochemistry [J Inorg Biochem] 2004 Jun; Vol. 98 (6), pp. 1143-50. - Publication Year :
- 2004
-
Abstract
- Three novel asymmetric ligands, 3-(pyridine-2-yl)-5,6-diphenyl-as-triazine (pdtb), 3-(pyridine-2-yl)-as-triazino[5,6-f]acenaphthylene (pdta) and 3-(pyridine-2-yl)-as-triazino[5,6-f]phenanthroline (pdtp) and their cobalt(III) complexes have been synthesized and characterized. Binding of the three complexes with calf thymus DNA (CT-DNA) has been investigated by spectroscopic methods, viscosity, cyclic voltammetry, and electrophoresis measurements. The experimental results indicate that the size and shape of the intercalated ligand have a marked effect on the binding affinity of complexes to CT-DNA. Complexes 2 and 3 have also been found to promote cleavage of plasmid pBR322 DNA from the supercoiled form I to the open circular form II upon irradiation.
- Subjects :
- Acenaphthenes chemical synthesis
Animals
Cattle
Ligands
Organometallic Compounds chemical synthesis
Phenanthrolines chemical synthesis
Photochemistry
Pyridines chemical synthesis
Triazines chemical synthesis
Acenaphthenes chemistry
Cobalt chemistry
DNA chemistry
Organometallic Compounds chemistry
Phenanthrolines chemistry
Plasmids chemistry
Pyridines chemistry
Triazines chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 0162-0134
- Volume :
- 98
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of inorganic biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 15149826
- Full Text :
- https://doi.org/10.1016/j.jinorgbio.2004.04.003