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Radiation recall dermatitis, panniculitis, and myositis following cyclophosphamide therapy: histopathologic findings of a patient affected by multiple myeloma.
- Source :
-
The American Journal of dermatopathology [Am J Dermatopathol] 2004 Jun; Vol. 26 (3), pp. 213-6. - Publication Year :
- 2004
-
Abstract
- Radiation recall dermatitis is one of the skin sequelae that may affect oncology patients. It occurs in a previously irradiated field, when subsequent chemotherapy is given. The eruption may be elicited by chemotherapy, even several months after radiotherapy. Its mechanism is poorly understood, and the histopathologic findings have received, to date, only sketchy descriptions. A 55-year-old male affected by multiple myeloma received radiation therapy both on his left coxofemoral area, and lumbar region (D11-L1). After cyclophosphamide administration, he developed 2 well defined square-shaped, infiltrated erythematoviolaceous plaques in the prior irradiated fields. Histopathologic findings revealed a diffusely fibrosclerosing process, involving deep dermis, hypodermis, as well as the underlying muscle, while sparing the epidermis and superficial-mid dermis. Histopathology was indistinguishable from deep radio-dermatitis, panniculitis, and myositis. This is the first case providing clear evidence of the causative role of cyclophosphamide in inducing a cutaneous and subcutaneous radiation recall reaction.
- Subjects :
- Combined Modality Therapy
Humans
Male
Middle Aged
Multiple Myeloma pathology
Myositis pathology
Panniculitis pathology
Radiodermatitis pathology
Radiotherapy
Antineoplastic Agents, Alkylating adverse effects
Cyclophosphamide adverse effects
Multiple Myeloma therapy
Myositis etiology
Panniculitis etiology
Radiodermatitis etiology
Subjects
Details
- Language :
- English
- ISSN :
- 0193-1091
- Volume :
- 26
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- The American Journal of dermatopathology
- Publication Type :
- Academic Journal
- Accession number :
- 15166509
- Full Text :
- https://doi.org/10.1097/00000372-200406000-00008