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Toxic effects of natural piperine and its derivatives on epimastigotes and amastigotes of Trypanosoma cruzi.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2004 Jul 05; Vol. 14 (13), pp. 3555-8. - Publication Year :
- 2004
-
Abstract
- We describe herein an evaluation of trypanocidal effects of the natural alkaloid piperine and twelve synthetic derivatives against epimastigote and amastigote forms of the protozoan parasite Trypanosoma cruzi, the causative agent of the incurable human disease, Chagas' disease. The results obtained point to piperine as a suitable template for the development of new drugs with trypanocidal activity.
- Subjects :
- Alkaloids isolation & purification
Alkaloids pharmacology
Animals
Benzodioxoles
Cells, Cultured
Chagas Disease drug therapy
Dose-Response Relationship, Drug
Drug-Related Side Effects and Adverse Reactions
Humans
Inhibitory Concentration 50
Parasitic Sensitivity Tests
Piperidines isolation & purification
Piperidines pharmacology
Polyunsaturated Alkamides
Trypanocidal Agents isolation & purification
Trypanocidal Agents pharmacology
Trypanosoma cruzi growth & development
Alkaloids chemistry
Piperidines chemistry
Trypanocidal Agents chemistry
Trypanosoma cruzi drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 0960-894X
- Volume :
- 14
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 15177472
- Full Text :
- https://doi.org/10.1016/j.bmcl.2004.04.019