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Beta-globin gene cluster haplotypes linked to the betaS gene in western India.

Authors :
Mukherjee MB
Surve RR
Gangakhedkar RR
Ghosh K
Colah RB
Mohanty D
Source :
Hemoglobin [Hemoglobin] 2004 May; Vol. 28 (2), pp. 157-61.
Publication Year :
2004

Abstract

The present survey, which involves 70 sickle cell anemia patients from Gujarat and Maharashtra revealed a high prevalence of the typical Arab-Indian haplotype (91.5 %). Six atypical haplotypes, including a Cameroon one were also found. Correlation of these various haplotypes with HbF expression was studied.

Subjects

Subjects :
DNA Mutational Analysis
Female
Hemoglobin, Sickle
Humans
Male
Polymorphism, Restriction Fragment Length
Anemia, Sickle Cell epidemiology
Anemia, Sickle Cell genetics
Globins genetics
Haplotypes genetics
India epidemiology
Multigene Family genetics

Details

Language :
English
ISSN :
0363-0269
Volume :
28
Issue :
2
Database :
MEDLINE
Journal :
Hemoglobin
Publication Type :
Academic Journal
Accession number :
15182059
Full Text :
https://doi.org/10.1081/hem-120034247
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