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Expanding roles for miRNAs and siRNAs in cell regulation.
- Source :
-
Current opinion in cell biology [Curr Opin Cell Biol] 2004 Apr; Vol. 16 (2), pp. 127-33. - Publication Year :
- 2004
-
Abstract
- The role of small RNAs as key regulators of mRNA turnover and translation has been well established. Recent advances indicate that the small RNAs termed microRNAs play important roles in cell proliferation, apoptosis and differentiation. Moreover, the microRNA mechanism is an efficient means to regulate production of a diverse range of proteins. As new microRNAs and their mRNA targets rapidly emerge, it is becoming apparent that RNA-based regulation of mRNAs may rival ubiquitination as a mechanism to control protein levels.
- Subjects :
- Animals
Gene Expression Regulation genetics
Gene Silencing physiology
Heterochromatin genetics
Heterochromatin metabolism
Humans
MicroRNAs biosynthesis
MicroRNAs genetics
RNA, Small Interfering biosynthesis
RNA, Small Interfering genetics
MicroRNAs physiology
Proteins metabolism
RNA, Messenger metabolism
RNA, Small Interfering physiology
Subjects
Details
- Language :
- English
- ISSN :
- 0955-0674
- Volume :
- 16
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Current opinion in cell biology
- Publication Type :
- Academic Journal
- Accession number :
- 15196554
- Full Text :
- https://doi.org/10.1016/j.ceb.2004.02.006