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Brimonidine purite 0.15% versus dorzolamide 2% each given twice daily to reduce intraocular pressure in subjects with open angle glaucoma or ocular hypertension.
- Source :
-
The British journal of ophthalmology [Br J Ophthalmol] 2004 Jul; Vol. 88 (7), pp. 953-6. - Publication Year :
- 2004
-
Abstract
- Background/aims: To evaluate the efficacy of brimonidine purite versus dorzolamide given twice daily in primary open angle glaucoma or ocular hypertensive subjects.<br />Methods: In this double masked, multicentre, prospective, crossover comparison 33 subjects were randomised to brimonidine purite or dorzolamide for the first 4 week treatment period after a 4 week washout. Subjects began the opposite treatment for the second 4 week period after another 4 week washout. Intraocular pressure (IOP) was measured at 08:00 (trough) and 10:00, 18:00, and 20:00 hours after dosing at each baseline and at the end of each treatment period.<br />Results: The baseline diurnal IOP was 22.9 (SD 2.8) for brimonidine purite and 22.2 (SD 2.4) mm Hg for dorzolamide. The trough IOP following 4 weeks of therapy was 21.0 (SD 3.7) for brimonidine purite and 21.0 (SD 3.1) mm Hg for dorzolamide (p = 0.90). The mean diurnal IOP was 19.3 (SD 3.1) for brimonidine purite and 19.8 (SD 2.4) mm Hg for dorzolamide (p = 0.46). Dorzolamide caused more ocular stinging upon instillation (n = 8) than brimonidine purite (n = 1) (p = 0.02). No statistical differences existed between groups for systemic adverse events.<br />Conclusions: This study suggests that brimonidine purite and dorzolamide each given twice daily have similar efficacy in primary open angle glaucoma or ocular hypertensive subjects. However, a trend was observed at 10:00 of greater brimonidine purite efficacy compared with dorzolamide.
- Subjects :
- Antihypertensive Agents adverse effects
Brimonidine Tartrate
Cross-Over Studies
Double-Blind Method
Drug Administration Schedule
Female
Humans
Male
Middle Aged
Prospective Studies
Quinoxalines adverse effects
Sulfonamides adverse effects
Thiophenes adverse effects
Antihypertensive Agents administration & dosage
Glaucoma, Open-Angle drug therapy
Intraocular Pressure drug effects
Ocular Hypertension drug therapy
Quinoxalines administration & dosage
Sulfonamides administration & dosage
Thiophenes administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 0007-1161
- Volume :
- 88
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The British journal of ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 15205246
- Full Text :
- https://doi.org/10.1136/bjo.2003.032979