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No gender differences in the progression of nervous system disease in HIV infection.
- Source :
-
Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2004 Jul 01; Vol. 36 (3), pp. 817-22. - Publication Year :
- 2004
-
Abstract
- The past decade has seen a marked increase in the number of HIV-infected women in the United States. There has been recent concern that HIV disease in general may progress more rapidly in women than men, and some studies, primarily retrospective reviews, have suggested higher rates of neurologic disease among females. The objective of this study was to assess gender differences in HIV-related central and peripheral nervous system disease over time. Participants were enrolled in a longitudinal cohort study at the University of North Carolina and had annual follow-up evaluations. At baseline, 42 HIV-negative females, 52 HIV-positive females, and 52 HIV-positive males were compared for age, education, mode of infection, absolute CD4 cell count, and plasma/cerebrospinal fluid HIV RNA load. Subjects were evaluated by standardized clinical neurologic, neuropsychological, and laboratory examinations every year. The results indicated that both HIV-positive males and HIV-positive females had poorer neurologic functioning than the control group. However, there was no evidence from the parameters measured that the rate of decline differed between HIV-positive males and HIV-positive females.
- Subjects :
- AIDS Dementia Complex physiopathology
AIDS Dementia Complex psychology
AIDS Dementia Complex virology
Adult
Cohort Studies
Female
HIV-1 isolation & purification
Humans
Longitudinal Studies
Male
Nervous System physiopathology
Neuropsychological Tests
North Carolina
RNA, Viral blood
RNA, Viral cerebrospinal fluid
Sex Characteristics
AIDS Dementia Complex etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1525-4135
- Volume :
- 36
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of acquired immune deficiency syndromes (1999)
- Publication Type :
- Academic Journal
- Accession number :
- 15213565
- Full Text :
- https://doi.org/10.1097/00126334-200407010-00008