pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates in Portugal.

Authors :: Portugal I
Barreiro L
Moniz-Pereira J
Brum L
Source :: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2004 Jul; Vol. 48 (7), pp. 2736-8.
Publication Year :: 2004
Abstract: The nucleotide sequences of the pncA genes within 55 multidrug-resistant pyrazinamide-resistant Mycobacterium tuberculosis clinical isolates were determined. Fifty-three out of the 55 isolates were pyrazinamidase (PZase) negative. Four strains contained a wild-type pncA gene, and PZase activity was undetectable in two of these strains. Seven of the 18 identified pncA mutations found have not been described in previous studies.

Subjects :: Animals
Mutation genetics
Portugal epidemiology
Tuberculosis epidemiology
Tuberculosis microbiology
Amidohydrolases genetics
Antitubercular Agents pharmacology
Mycobacterium tuberculosis drug effects
Pyrazinamide pharmacology

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