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HLA-A and -B allele expression and ability to develop anti-Gag cross-clade responses in subtype C HIV-1-infected Ethiopians.
- Source :
-
Human immunology [Hum Immunol] 2004 Jun; Vol. 65 (6), pp. 648-59. - Publication Year :
- 2004
-
Abstract
- A cohort of 35 human immunodeficiency virus type 1 (HIV-1) subtype C-infected Ethiopians was studied to define the HLA phenotype in all 35 subjects and highly conserved Gag protein regions involved in cross-clade cell-mediated immunity. Full-length Gag virus sequences were determined in 15 individuals. CD8 cell-mediated immune responses were detected by interferon-gamma ELISpot assay. HLA-A*03, -B*49, and -B*57 allelic frequencies were relatively higher than in other African populations. Anti-p17 (aa 1-60) CD8+ were detectable in the highest number of individuals. Anti-p17 (aa 1-60 and 51-110) cross-clade responses against subtype B and C were detected in 50% of the tested subjects. The p24 KF11 (aa 162-172) epitope was found to be immunodominant among the HLA-B*5703--positive individuals. These data represent the first report of correlating HLA phenotype and HIV-specific cell-mediated immune responses among infected Ethiopians and may be useful in designing cytotoxic T lymphocyte-inducing vaccines for this part of Africa.
- Subjects :
- AIDS Vaccines immunology
Ethiopia
Female
Gene Products, gag genetics
HIV Infections immunology
HIV Infections prevention & control
HIV-1 genetics
HLA-A Antigens immunology
HLA-B Antigens immunology
Humans
Immunity, Cellular immunology
Interferon-gamma immunology
Male
Phenotype
T-Lymphocytes, Cytotoxic immunology
Gene Products, gag immunology
HIV Infections genetics
HIV-1 immunology
HLA-A Antigens genetics
HLA-B Antigens genetics
Immunity, Cellular genetics
Subjects
Details
- Language :
- English
- ISSN :
- 0198-8859
- Volume :
- 65
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Human immunology
- Publication Type :
- Academic Journal
- Accession number :
- 15219385
- Full Text :
- https://doi.org/10.1016/j.humimm.2004.02.031