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Population-based laboratory surveillance for Escherichia coli-producing extended-spectrum beta-lactamases: importance of community isolates with blaCTX-M genes.

Authors :
Pitout JD
Hanson ND
Church DL
Laupland KB
Source :
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2004 Jun 15; Vol. 38 (12), pp. 1736-41. Date of Electronic Publication: 2004 May 25.
Publication Year :
2004

Abstract

A prospective, population-based laboratory surveillance study was conducted to define the epidemiology of extended-spectrum beta -lactamase-producing Escherichia coli infections in the Calgary Health Region during the years 2000-2002. The incidence was 5.5 cases per 100,000 population per year. The annualized incidence of 3.9 cases per 100,000 population for January through March was significantly lower than the incidence for the other quarters of the year (6.0 per 100,000 population; P<.01). Seventy-one percent of subjects had community-onset disease. Patients aged > or =65 years (22.0 vs. 3.8 cases per 100,000 population per year; P<.0001) and women (9.2 vs. 1.7 cases per 100,000 population per year; P<.0001) had significantly higher rates of infection. Polymerase chain reaction identified 23 (15%) of 157 isolates as positive for blaCTX-M genes from the CTX-M-I subgroup and 87 (55%) from the CTX-M-III subgroup. Ciprofloxacin resistance was independently associated with CTX-M- beta -lactamases (odds ratio, 14.2; 95% confidence interval, 3.69-54.84). Strains of E. coli with blaCTX-M genes commonly cause community-onset infections, and women and older patients are at highest risk.

Details

Language :
English
ISSN :
1537-6591
Volume :
38
Issue :
12
Database :
MEDLINE
Journal :
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Publication Type :
Academic Journal
Accession number :
15227620
Full Text :
https://doi.org/10.1086/421094