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CNS grafts of rat choroid plexus protect against cerebral ischemia in adult rats.
- Source :
-
Neuroreport [Neuroreport] 2004 Jul 19; Vol. 15 (10), pp. 1543-7. - Publication Year :
- 2004
-
Abstract
- The present study examined the neuroprotective effects of choroid plexus isolated from adult rats and encapsulated within alginate microcapsules. In vitro, conditioned media from cultured choroid plexus produced a marked, dose-dependent protection of embryonic cortical neurons against serum deprivation-induced cell death. In vivo studies demonstrated that a one-hour middle cerebral artery occlusion in adult Wistar rats produced profound motor and neurological impairments 1-3 days after stroke. In contrast, stroke animals transplanted with encapsulated choroid plexus cells displayed a significant reduction in both motor and neurological abnormalities. Histological analysis 3 days post-transplantation revealed that choroid plexus transplants significantly decreased the volume of striatal infarction. This is the first report demonstrating the therapeutic potential of transplanted choroid plexus for stroke.
- Subjects :
- Analysis of Variance
Animals
Behavior
Brain Ischemia pathology
Capsules therapeutic use
Cell Death drug effects
Cell Survival drug effects
Cells, Cultured
Cerebral Cortex cytology
Cerebral Infarction pathology
Cerebral Infarction surgery
Culture Media, Conditioned pharmacology
Dose-Response Relationship, Drug
Embryo, Mammalian
Graft Survival physiology
Locomotion physiology
Male
Motor Activity physiology
Neurons drug effects
Rats
Rats, Wistar
Tetrazolium Salts
Time Factors
Brain Ischemia prevention & control
Brain Tissue Transplantation methods
Choroid Plexus cytology
Choroid Plexus physiology
Neurons transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 0959-4965
- Volume :
- 15
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Neuroreport
- Publication Type :
- Academic Journal
- Accession number :
- 15232280
- Full Text :
- https://doi.org/10.1097/01.wnr.0000133298.84901.cf