Back to Search
Start Over
Synthesis and characterization of PEG dimethacrylates and their hydrogels.
- Source :
-
Biomacromolecules [Biomacromolecules] 2004 Jul-Aug; Vol. 5 (4), pp. 1280-7. - Publication Year :
- 2004
-
Abstract
- Facile synthesis and detailed characterization of photopolymerizable and biocompatible poly(ethylene glycol) dimethacrylates (PEGDM) and poly(ethylene glycol) urethane-dimethacrylates (PEGUDM) are described. Poly(ethylene glycol)s of various molecular masses (M(n) = 1000 to 8000 g/mol) were reacted with methacrylic anhydride or with 2-isocyanatoethyl methacrylate to form PEGDMs and PEGUDMs, respectively. PEGDMs were also prepared by a microwave-assisted route to achieve fast reaction conversions under solvent free conditions. Combined analyses of (1)H NMR and MALDI-TOF MS confirmed the formation of prepolymers of high purity and narrow mass distribution (PD < 1.02). Aqueous solutions of the PEGDMs and PEGUDMs (10% and 20% by mass fraction) were photopolymerized to yield hydrogels. Bovine chondrocytes, seeded in the hydrogels, were used to assess the biocompatibility. Preliminary rheology and uniaxial compression measurements showed varied mechanical response, and biocompatibility studies showed that cells are completely viable in both types of hydrogels after two weeks.
- Subjects :
- Animals
Cattle
Cell Survival drug effects
Methacrylates pharmacology
Molecular Structure
Molecular Weight
Polyethylene Glycols chemical synthesis
Polyurethanes chemical synthesis
Polyurethanes chemistry
Polyurethanes pharmacology
Hydrogels chemical synthesis
Hydrogels chemistry
Methacrylates chemical synthesis
Methacrylates chemistry
Polyethylene Glycols chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1525-7797
- Volume :
- 5
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Biomacromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 15244441
- Full Text :
- https://doi.org/10.1021/bm0498777