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Neural correlates of action attribution in schizophrenia.
- Source :
-
Psychiatry research [Psychiatry Res] 2004 May 30; Vol. 131 (1), pp. 31-44. - Publication Year :
- 2004
-
Abstract
- Patients with first-rank symptoms (FRS) of schizophrenia do not experience all of their actions and personal states as their own. FRS may be associated with an impaired ability to correctly attribute an action to its origin. In the present study, we examined regional cerebral blood flow (rCBF) with positron emission tomography during an action-attribution task in a group of patients with FRS. We used a device previously used with healthy subjects that allows the experimenter to modulate the subject's degree of movement control (and thus action attribution) of a virtual hand presented on a screen. In healthy subjects, the activity of the right angular gyrus and the insula cortex appeared to be modulated by the subject's degree of movement control of the virtual hand. In the present study, the schizophrenic patients did not show this pattern. We found an aberrant relationship between the subject's degree of control of the movements and rCBF in the right angular gyrus and no modulation in the insular cortex. The implications of these results for understanding pathological conditions such as schizophrenia are discussed.
- Subjects :
- Adult
Brain diagnostic imaging
Brain Mapping
Cerebral Cortex diagnostic imaging
Cerebral Cortex physiopathology
Delusions diagnostic imaging
Delusions psychology
Gyrus Cinguli diagnostic imaging
Gyrus Cinguli physiopathology
Humans
Male
Nerve Net diagnostic imaging
Nerve Net physiopathology
Neural Analyzers diagnostic imaging
Neural Analyzers physiopathology
Schizophrenia diagnostic imaging
Brain physiopathology
Delusions physiopathology
Image Processing, Computer-Assisted
Imaging, Three-Dimensional
Internal-External Control
Perceptual Distortion physiology
Psychomotor Performance physiology
Schizophrenia physiopathology
Schizophrenic Psychology
Tomography, Emission-Computed, Single-Photon
User-Computer Interface
Subjects
Details
- Language :
- English
- ISSN :
- 0165-1781
- Volume :
- 131
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Psychiatry research
- Publication Type :
- Academic Journal
- Accession number :
- 15246453
- Full Text :
- https://doi.org/10.1016/j.pscychresns.2004.02.004