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Executive functioning, illness course, and relapse/recurrence in continuation and maintenance treatment of late-life depression: is there a relationship?
- Source :
-
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry [Am J Geriatr Psychiatry] 2004 Jul-Aug; Vol. 12 (4), pp. 387-94. - Publication Year :
- 2004
-
Abstract
- Objective: The authors tested the hypothesis that impaired executive functioning leads to high rates of relapse and recurrence in late-life depression.<br />Methods: They analyzed data from subjects participating in two independent intervention trials. Study I included 53 elderly depressed patients who participated in an open trial comparing the efficacy of paroxetine and nortriptyline and recurrence prevention over 18 months. Study II focused on 146 elderly depressed patients who received open treatment with paroxetine in a relapse-prevention study over 4 months of continuation treatment. They examined the effect of cognitive functioning, in general, and executive functioning, in particular, on time-to-relapse/recurrence, using baseline and post-treatment measures of neuropsychological functioning.<br />Results: The associations between cognitive measures and both probability of, and time-to-relapse/recurrence were small and statistically nonsignificant.<br />Conclusion: Data failed to support the hypothesis that cognitive impairment, in general, or executive dysfunction, in particular, predicts relapse or recurrence of major depression in late life. Authors recommend future testing of the hypothesis with detailed, comprehensive measures over longer periods of observation during maintenance trials.
- Subjects :
- Age of Onset
Aged
Cognition Disorders diagnosis
Diagnostic and Statistical Manual of Mental Disorders
Disease Progression
Female
Humans
Male
Neuropsychological Tests
Recurrence
Antidepressive Agents, Tricyclic therapeutic use
Cognition Disorders epidemiology
Cognition Disorders etiology
Depressive Disorder, Major diagnosis
Depressive Disorder, Major drug therapy
Depressive Disorder, Major epidemiology
Nortriptyline therapeutic use
Paroxetine therapeutic use
Selective Serotonin Reuptake Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1064-7481
- Volume :
- 12
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 15249276
- Full Text :
- https://doi.org/10.1176/appi.ajgp.12.4.387