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Fat chance: genetic syndromes with obesity.

Authors :
Delrue MA
Michaud JL
Source :
Clinical genetics [Clin Genet] 2004 Aug; Vol. 66 (2), pp. 83-93.
Publication Year :
2004

Abstract

Although obesity shows high heritability, we are aware of only a small number of genes that affect adipose mass in humans. Genetic syndromes with obesity represent unique opportunities to gain insight into the control of energy balance. The majority of obesity syndromes can be distinguished by the presence of mental retardation. We performed a systematic search of such syndromes and reviewed the literature with a focus on distinguishing clinical features, the characteristics of their obesity, and the underlying pathogenetic mechanisms. We predict that the study of these conditions will shed light on common forms of obesity.<br /> (Copyright 2004 Blackwell Munksgaard)

Details

Language :
English
ISSN :
0009-9163
Volume :
66
Issue :
2
Database :
MEDLINE
Journal :
Clinical genetics
Publication Type :
Academic Journal
Accession number :
15253756
Full Text :
https://doi.org/10.1111/j.0009-9163.2004.00300.x