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Functional expression of CD134 by neutrophils.
- Source :
-
European journal of immunology [Eur J Immunol] 2004 Aug; Vol. 34 (8), pp. 2268-75. - Publication Year :
- 2004
-
Abstract
- CD134 (OX40) is a member of the tumor necrosis factor (TNF) receptor superfamily expressed on activated T cells. Here, we show that human peripheral blood neutrophils express CD134. Activation of CD134 by soluble CD134 ligand (OX40 ligand/gp34) resulted in delayed caspase-3 activation and consequently in delayed neutrophil apoptosis in vitro. Moreover, CD134 ligand, like G-CSF, maintained anti-apoptotic Mcl-1 levels and inhibited cleavage of the pro-apoptotic Bcl-2 family members Bid and Bax in these cells, suggesting that CD134-mediated signals block apoptosis pathways proximal to mitochondria activation. In conclusion, CD134 regulates neutrophil survival, suggesting that this molecule does not only contribute to adaptive but also to innate immune responses.
- Subjects :
- Apoptosis physiology
BH3 Interacting Domain Death Agonist Protein
Carrier Proteins metabolism
Caspase 3
Caspases metabolism
Humans
Myeloid Cell Leukemia Sequence 1 Protein
Neoplasm Proteins metabolism
Neutrophils physiology
Proto-Oncogene Proteins metabolism
Receptors, OX40
Receptors, Tumor Necrosis Factor agonists
bcl-2-Associated X Protein
Neutrophils immunology
Proto-Oncogene Proteins c-bcl-2
Receptors, Tumor Necrosis Factor immunology
Subjects
Details
- Language :
- English
- ISSN :
- 0014-2980
- Volume :
- 34
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- European journal of immunology
- Publication Type :
- Academic Journal
- Accession number :
- 15259024
- Full Text :
- https://doi.org/10.1002/eji.200424863